Context matters when decoding Jenny's terminal condition. The timeline of the movie places Forrest and Jenny’s reunion in Savannah in roughly 1981. This timing matches the dawn of the 1980s healthcare crisis, when American medical teams first began documenting rare clusters of pneumocystis pneumonia and Kaposi's sarcoma in major urban hubs. Because Jenny spent the late 1960s and 1970s embedded in high-risk counterculture scenes marked by intravenous drug use and transient communal living, viewers instinctively connected her undiagnosed status to the HIV AIDS epidemic.
Medical realities tell a different story. Hepatitis C was widespread yet officially unclassified throughout the 1970s and early 1980s. Clinicians routinely called it "non-A, non-B hepatitis" until researchers officially isolated the virus in 1989. When Jenny told Forrest that doctors had no name for her sickness, her description matched the clinical reality of thousands of patients with end-stage liver disease during that decade. While HIV symptoms were rapidly categorized under public health alerts starting in 1982, Hepatitis C remained a literal "unknown virus" to community doctors throughout the exact window Jenny fell ill.
Screenwriter Eric Roth settled the dispute years later. In discussions regarding his scrapped screenplay for a sequel, Roth confirmed that Jenny died from complications of Hepatitis C. He envisioned an opening scene where Forrest sat outside an elementary school, terrified that other parents would shun his son because of the lingering societal paranoia surrounding the mother's death.