Q1: Does Bane of Arthropods work on the Ender Dragon or the Wither?
A1: No. Neither boss possesses the arthropod tag. The Wither is classified as undead (weak to Smite), and the Ender Dragon takes extra damage only from general attacks boosted by Sharpness.
Q2: Can I combine Bane of Arthropods with Fire Aspect and Looting?
A2: Yes. Bane of Arthropods conflicts strictly with Sharpness and Smite. You can freely combine it with Looting, Fire Aspect, Unbreaking, Mending, and Knockback on the same weapon.
Q3: Is Bane of Arthropods worth using on a Netherite sword?
A3: Only if you already own a primary Netherite sword enchanted with Sharpness V or Smite V. Devoting your sole high-tier weapon to Bane of Arthropods severely reduces your damage output against skeletons, zombies, and general Overworld hostiles.