Throughout his rise, Irfani maintained a private personal life, deliberately separating domestic peace from celebrity spectacle. He married Maryam Shafaat in an intimate ceremony in 2010. During an era when social media pushes celebrity couples into relentless public exposure, Irfani kept his marriage grounded, occasionally posting heartfelt birthday messages while protecting his family from public scrutiny.
In May 2023, the family suffered a profound heartbreak when their young son, Zaviyar Irfani, passed away. The sudden loss sent shockwaves through the Pakistani entertainment community, prompting an outpouring of condolences from fellow actors, directors, and fans worldwide.
Irfani stepped away from screen work for over a year to grieve with his wife and family. When he spoke publicly about the loss in mid-2024, his reflections showed quiet courage rather than performative sorrow. Quoting the famous maxim, "Don't cry because it's over, smile because it happened," Irfani shared how holding deep gratitude for his son's life kept him anchored through grief. That loss fundamentally changed his artistic lens. When Irfani returned to screens in late 2024 and 2025, his work revealed an emotional depth that elevated his performances beyond standard leading-man roles.