Long before it became a mainstay of Mexican Spanish colloquialisms, the word had an anatomical definition. The term traces back to the Vulgar Latin pectiniculus, a diminutive of pecten, meaning comb or pubic bone. In archaic Castilian Spanish, the word pendejo literally designated a single strand of pubic hair.
Centuries ago, Spanish vernacular adapted the term to describe prepubescent adolescents who were sprouting their first body hair. Older men used the label dismissively toward teenagers who acted tough despite possessing zero life experience or wisdom. The word carried the implication of being cowardly, immature, and fundamentally naive. Over the 18th and 19th centuries, the literal anatomical meaning faded into obscurity across the Spanish-speaking Americas, leaving behind a sharp, figurative insult for someone devoid of sense.
Modern gender inflection follows standard Spanish grammatical mechanics. The base noun pendejo applies to males or serves as a generic masculine noun, while pendeja explicitly targets a female subject. Transforming the masculine "-o" to the feminine "-a" does not alter the fundamental intensity of the insult, but it specifies the target with precision. In rapid speech, substituting one suffix for another without tracking grammatical gender represents one of the most common conversational Spanish mistakes made by beginner learners.