Acker's filmography spans independent Shakespearean features, franchise television, and primetime science fiction. Rather than remaining bound to one genre, she consistently pivoted across network procedurals and fantasy adaptations.
| Production Title | Active Run | Character Portrayed | Key Impact & Recognition |
|---|---|---|---|
| Angel | 2001, 2004 | Winifred "Fred" Burkle / Illyria | Saturn Award for Best Supporting Actress (2003) |
| Alias | 2005, 2006 | Kelly Peyton | Primary antagonist operative in final season |
| Much Ado About Nothing | 2012 | Beatrice | Critically acclaimed indie theatrical lead |
| Person of Interest | 2012, 2016 | Samantha "Root" Groves / The Machine | Cult status; 65 episodes as central protagonist/AI |
| The Gifted | 2017, 2019 | Caitlin Strucker | Fox/Marvel series lead across 29 episodes |
In 2017, Fox and Marvel Television selected Acker to co-lead the X-Men offshoot The Gifted as Caitlin Strucker. Playing a human mother forced to defend her mutant children against government agencies gave her a platform to portray grounded parental vulnerability without relying on superpowers.
